The evaluation of liver dysfunction and oxidative stress due to urban environmental pollution in Mexican population related to Madin Dam, State of Mexico: a pilot study.

One of the most important causes of disease and premature death in the world is environmental pollution. The presence of pollutants in both water and air contributes to the deterioration of the health of human populations. The Mexico City Metropolitan Area is one of the most populous and affected by air pollution worldwide; in addition, in recent years there has been a growing demand for water, so urban reservoirs such as the Madin dam are vital to meet the demand. However, this reservoir is highly polluted due to the urban settlements around it. Therefore, the aim of the present study was to evaluate oxidative stress in clinically healthy subjects by means of the degree of lipoperoxidation, as well as the modification of serum enzyme levels, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase associated with air and drinking water pollutants from three zones of the Mexico City Metropolitan Area, two of them related to Madin Dam. This descriptive cross-sectional study was conducted between March 2019 and September 2021 in 142 healthy participants (age range 18-65 years). Healthy subjects were confirmed by their medical history. The results showed that chronic exposure to air (SO2) and water pollutants (Al and Fe) was significantly associated with elevated levels of lipoperoxidation. There was evidence that contamination from the Madín dam can generate oxidative stress and affect the health status of people who receive water from this reservoir or who consume fish that inhabit it.

Larva migrans cutánea / Cutaneous larva migrans

Larva migrans cutánea, es una ectoparasitosis producida por la penetración percutánea y migración de larvas de parásitos nemátodes, adquiridos por contacto corporal con tierra contaminada con deposiciones de perros y gatos.

Asociación entre la proteína p53 mutada, grado de infiltración y tamaño del tumor en cáncer colorrectal. Hospital Central FAP 1987-1996 / Association between p53 mutations with tumoral size and dukes stage among patients with colorectal carcinoma at the Hospital Central FAP, 1987-1996

Determinar la presencia de proteína p53 mutada en pacientes con cáncer colorrectal, y correlacionarla con el tamaño del tumor y grado de infiltración (Dukes). Se estudio retrospectivamente 40 muestras de casos diagnosticados como carcinoma colorrectal de los registros del Hospital Central FAP, entre los años 1987-1996. Se empleo el método inmunohistoquímico estreptavidina-biotina peroxidasa con el anticuerpo do-7 y con pretratamiento con microondas para la demostración de proteína p53 mutada. Todos los caso feuron adenocarcinomas enla gran mayoría medianamente diferenciados, 18 pertenecian a la clasificación Dukes B, 16 a Dukes C, 4 a Dukes A y 2 a Dukes D. El tamaño del tumor era directamente proporcional al grado de infiltración con un promedio de 5,5 cm3 para Dukes A y 50,12 cm3 para Dukes D. La presencia total de proteína p53 mutada fue 55 por ciento, la positividad fue creciendo según el grado de infiltración del tumor (a=0,376). Entre los casos estudiados, la cumulación de proteína p53 mutada estuvo en relación directa al tamaño y grado de infiltración del tumor.